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KMID : 0361619960310020381
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Journal of the Korean Orthopaedic Association
1996 Volume.31 No. 2 p.381 ~ p.387
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A Study of 3 Cases of Synovial Sarcoma by Immunohistochemical Stain, Electron Microscopy
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하상호
이상홍/신동민/이미숙/전호종
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Abstract
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Synovial sarcoma is a distinct and generally recognized soft tissue tumor that it's origin still raises controversy. The synovial origin of synovial sarcoma has not been determined despite the accepted terminology implying synovium as stem cell.
Three
cases of primary synovial sarcoma has not been determined despite the accepted terminology implying synovium as stem cell. Three cases of primary synovial sarcoma (2 fibrous monophasic, 1 biphasic type) were studied with a panel of antibodies
against
different types of cytokeratin and other markers (EMA, CEA, vimentin, S-100 protein, lysozyme, 1-antichymotrypsin). Spindle shaped-cell in monophasic synovial sarcoma showed reactivity for CK7 and pancytokeratin. Epithelial cells lining of glands
in
biphasic synovial sarcoma reactive for CK7, pancytoekeratin, EMA, and focally CEA but spindle cells only positive for vimentin. By electron microscopy, fibrous monophasic synovial sarcoma showed pseudogland formation with intercellular junctions
of
paired subplasmalemmal density and discontinuous basal lamina. These results indicate that synovial sarcoma showes epithelial differentiation. We believe that synovial sarcoma arises in pluripotential connective tissue cells that is able to be
differentiated into both mesenchymal and epithelial components. So synovial sarcoma have been considered carcinosarcoma of soft tissues depending on the type of differentiation.
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KEYWORD
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